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Article

Birth Cohort, Age, and Sex Strongly Modulate Effects of Lipid Risk Alleles Identified in Genome-Wide Association Studies.

PloS one - 1 Jan 2015

Kulminski Alexander M, Culminskaya Irina, Arbeev Konstantin G, Arbeeva Liubov, Ukraintseva Svetlana V, Stallard Eric, Wu Deqing, Yashin Anatoliy I

Abstract excerpt

Insights into genetic origin of diseases and related traits could substantially impact strategies for improving human health. The results of genome-wide association studies (GWAS) are often positioned as discoveries of unconditional risk alleles of complex health traits. We re-analyzed the associations of single nucleotide polymorphisms (SNPs) associated with total cholesterol (TC) in a large-scale GWAS...

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Source

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Identifiers

PMID: 26295473
DOI: 10.1371/journal.pone.0136319
PMCID: PMC4546650

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PCSK9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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