Article
Genetic variants and their interactions in the prediction of increased pre-clinical carotid atherosclerosis: the cardiovascular risk in young Finns study.
PLoS genetics - 30 Sept 2010
Okser Sebastian, Lehtimäki Terho, Elo Laura L, Mononen Nina, Peltonen Nina, Kähönen Mika, Juonala Markus, Fan Yue-Mei, Hernesniemi Jussi A, Laitinen Tomi, Lyytikäinen Leo-Pekka, Rontu Riikka, Eklund Carita, Hutri-Kähönen Nina, Taittonen Leena, Hurme Mikko, Viikari Jorma S A, Raitakari Olli T, Aittokallio Tero
Abstract excerpt
The relative contribution of genetic risk factors to the progression of subclinical atherosclerosis is poorly understood. It is likely that multiple variants are implicated in the development of atherosclerosis, but the subtle genotypic and phenotypic differences are beyond the reach of the conventional case-control designs and the statistical significance testing procedures being used in most association...
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