Article

The fluorescent ligand bTVBT2 reveals increased p-tau uptake by retinal microglia in Alzheimer’s disease patients and AppNL-F/NL-F mice

2023-07-21

Abstract excerpt

<h4>Background: </h4> Amyloid beta (Ab) deposits and hyperphosphorylated tau (p-tau) accumulation have been identified in the retina of Alzheimer’s disease (AD) patients and transgenic AD mice. Previous studies have shown that retinal microglia engulf Ab, but this property decrease in AD patients. Whether retinal microglia also take up p-tau and if this event is affected in AD is yet not described. In the current...

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Literature Corpus work: b1912e2b-1653-51f3-b9ff-7f6154995958
DOI: 10.21203/rs.3.rs-3174481/v1

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