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Article

Activated microglia mitigate Aβ-associated tau seeding and spreading.

The Journal of experimental medicine - 2 Aug 2021

Gratuze Maud, Chen Yun, Parhizkar Samira, Jain Nimansha, Strickland Michael R, Serrano Javier Remolina, Colonna Marco, Ulrich Jason D, Holtzman David M

Abstract excerpt

In Alzheimer's disease (AD) models, AD risk variants in the microglial-expressed TREM2 gene decrease Aβ plaque-associated microgliosis and increase neuritic dystrophy as well as plaque-associated seeding and spreading of tau aggregates. Whether this Aβ-enhanced tau seeding/spreading is due to loss of microglial function or a toxic gain of function in TREM2-deficient microglia is unclear. Depletion of microglia in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34100905
DOI: 10.1084/jem.20210542
PMCID: PMC8190588

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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