Article
COX-2 gene variants in bipolar disorder-I.
Psychiatria Danubina - 1 Dec 2015
Ozdemircan Abdullah, Dasdemir Selcuk, Kucukali Cem Ismail, Bireller Elif Sinem, Ozturk Hamdi, Cakmakoglu Bedia
Abstract excerpt
BACKGROUND: Bipolar disorder-I (BD-I) is a complex illness, and multiple genes and environmental factors determine its pathogenesis. Several studies have ascertained that BD-I and inflammation are linked through shared genetic polymorphisms and gene expression, as well as altered cytokine levels. COX-2 gene polymorphisms affecting COX-2 levels may be associated with BD-I by altering the inflammatory response....
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