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Article

Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.

Inflammatory bowel diseases - 1 Apr 2011

Andersen Vibeke, Nimmo Elaine, Krarup Henrik B, Drummond Hazel, Christensen Jane, Ho Gwo-Tzer, Ostergaard Mette, Ernst Anja, Lees Charlie, Jacobsen Bent A, Satsangi Jack, Vogel Ulla

Abstract excerpt

BACKGROUND: Inflammatory bowel diseases (IBDs) are a result of interactions between luminal pathogens and the intestinal immune response. Cyclooxygenase-2 (COX-2) plays a key role in the regulation of the inflammatory response upon stimulation by luminal pathogens via Toll-like receptors. METHODS: Genotypes of the COX-2/PTGS2/PGHS2 A-1195G (rs689466), G-765C (rs20417), and T8473C (rs5275) polymorphisms were...

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Source

Identifiers

PMID: 20803508
DOI: 10.1002/ibd.21440

Genes

PTGS2

Variants

rs689466

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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