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Article

Functional polymorphisms in the cyclooxygenase 2 (COX-2) gene and risk of breast cancer in a Chinese population.

Journal of toxicology and environmental health. Part A - 1 Jun 2007

Gao Jun, Ke Qiao, Ma Hong-Xia, Wang Yan, Zhou Yan, Hu Zhi-Bin, Zhai Xiang-Jun, Wang Xue-Chen, Qing Jian-Wei, Chen Wen-Sen, Jin Guang-Fu, Liu Ji-Yong, Tan Yong-Fei, Wang Xin-Ru, Shen Hong-Bing

Abstract excerpt

Cyclooxygenase (COX), the rate-limiting enzyme in prostaglandins (PG) synthesis, exists in at least two isoforms, COX-1 and COX-2. COX-2 plays an important role in carcinogenesis, and overexpression may increase proliferation, inhibit apoptosis, and enhance the invasiveness of breast cancer cells. Polymorphisms in the regulatory regions of the COX-2 gene may influence function and/or expression and contribute to...

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PMID: 17479405
DOI: 10.1080/15287390701289966

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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