Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.

PloS one - 24 Nov 2010

de Vries Hilbert S, te Morsche Rene H M, van Oijen Martijn G H, Nagtegaal Iris D, Peters Wilbert H M, de Jong Dirk J

Abstract excerpt

BACKGROUND: Cyclooxygenase-2 (COX-2) is a key enzyme involved in the conversion of arachidonic acid into prostaglandins. COX-2 is mainly induced at sites of inflammation in response to proinflammatory cytokines such as interleukin-1α/β, interferon-γ and tumor necrosis factor-α produced by inflammatory cells. AIM: The aim of this study was to investigate the possible modulating effect of the functional COX-2...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chi-Square Distribution
Share to Colitis, Ulcerative

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Crohn Disease

Share to Cyclooxygenase 2

Share to Disease Progression

Share to Genetic Association Studies

Share to Netherlands

Share to Odds Ratio

Source

Open in PubMed Open full text

Identifiers

PMID: 21124790
DOI: 10.1371/journal.pone.0015011
PMCID: PMC2991351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The functional -765G→C polymorphism of the COX-2 gene may reduce the risk of developing crohn's disease.PMID 21124790Read ↗

Cyclooxygenase-2 (COX-2) polymorphisms and risk of inflammatory bowel disease in a Scottish and Danish case-control study.Semantic proximity Read ↗

COX-2 polymorphisms -765G-->C and -1195A-->G and colorectal cancer risk.Semantic proximity Read ↗

Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease.Semantic proximity Read ↗

Cyclooxygenase-2 polymorphisms and susceptibility to colorectal cancer: a meta-analysis.Semantic proximity Read ↗

The -765C allele of the cyclooxygenase-2 gene as a potential risk factor of colorectal cancer: a meta-analysis.Semantic proximity Read ↗

Potentially functional COX-2-1195G>A polymorphism increases the risk of digestive system cancers: a meta-analysis.Semantic proximity Read ↗

Meta-analysis of the association between COX-2 polymorphisms and risk of colorectal cancer based on case-control studies.Semantic proximity Read ↗

COX-2 polymorphisms in patients with familial adenomatous polyposis.Semantic proximity Read ↗

Investigation of TLR2 (-196 to -174del) and TLR9 (T-1486C) Gene Polymorphisms Association with Inflammatory Bowel Diseases.Semantic proximity Read ↗

Associations of functional polymorphisms in cyclooxygenase-2 and platelet 12-lipoxygenase with risk of occurrence and advanced disease status of colorectal cancer.Semantic proximity Read ↗

Cox-2 gene variants in migraine.Semantic proximity Read ↗

Association between COX-2 -1195G>A polymorphism and gastrointestinal cancer risk: A meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.