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Article

Counteraction of HLA-C-mediated immune control of HIV-1 by Nef.

Journal of virology - 1 Jul 2010

Specht Anke, Telenti Amalio, Martinez Raquel, Fellay Jacques, Bailes Elizabeth, Evans David T, Carrington Mary, Hahn Beatrice H, Goldstein David B, Kirchhoff Frank

Abstract excerpt

A host genetic variant (-35C/T) correlates with increased human leukocyte antigen C (HLA-C) expression and improved control of HIV-1. HLA-C-mediated immunity may be particularly protective because HIV-1 is unable to remove HLA-C from the cell surface, whereas it can avoid HLA-A- and HLA-B-mediated immunity by Nef-mediated down-modulation. However, some individuals with the protective -35CC genotype exhibit high...

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Share to CD8 Antigens
Share to Histocompatibility Antigens Class I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histocompatibility Antigens Class II

Share to HLA-C Antigens

Share to nef Gene Products, Human Immunodeficiency Virus

Share to NFATC Transcription Factors

Share to Recombinant Fusion Proteins

Share to Viral Load

Source

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Identifiers

PMID: 20463068
DOI: 10.1128/JVI.00619-10
PMCID: PMC2898263

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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