Article
A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.
Development (Cambridge, England) - 15 Dec 2015
Amakawa Yuko, Sakata Yuka, Hoki Yuko, Arata Satoru, Shioda Seiji, Fukagawa Tatsuo, Sasaki Hiroyuki, Sado Takashi
Abstract excerpt
The dosage difference of X-linked genes between the sexes in mammals is compensated for by genetic inactivation of one of the X chromosomes in XX females. A noncoding RNA transcribed from the Xist gene at the onset of X chromosome inactivation coats the X chromosome in cis and induces chromosome-wide heterochromatinization. Here, we report a new Xist allele (Xist(CAG)) driven by a CAG promoter, which is known to...
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