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Article

Regulation of imprinted X-chromosome inactivation in mice by <i>Tsix</i>

15 Apr 2001

Abstract excerpt

In mammals, X-chromosome inactivation is imprinted in the extra-embryonic lineages with paternal X chromosome being preferentially inactivated. In this study, we investigate the role of Tsix, the antisense transcript from the Xist locus, in regulation of Xist expression and X-inactivation. We show that Tsix is transcribed from two putative promoters and its transcripts are processed. Expression of Tsix is first...

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Share to Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
Share to Genetic Syndromes and Imprinting
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Identifiers

PMID: 11262229
DOI: 10.1242/dev.128.8.1275

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Regulation of imprinted X-chromosome inactivation in mice by <i>Tsix</i>PMID 11262229Read ↗

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A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice.Semantic proximity Read ↗

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A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.Semantic proximity Read ↗

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