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Article

Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.

Cytogenetic and genome research - 1 Jan 2006

Ohhata T, Hoki Y, Sasaki H, Sado T

Abstract excerpt

Differential induction of the X-linked non-coding Xist gene is a key event in the process of X inactivation occurring in female mammalian embryos. Xist is negatively regulated in cis by its antisense gene Tsix through modification of the chromatin structure. The maternal Xist allele, which is normally silent in the extraembryonic lineages, is ectopically activated when Tsix is disrupted on the same chromosome,...

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Identifiers

PMID: 16575199
DOI: 10.1159/000090851

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Tsix-deficient X chromosome does not undergo inactivation in the embryonic lineage in males: implications for Tsix-independent silencing of Xist.PMID 16575199Read ↗

Effect of TSIX disruption on XIST expression in male ES cells.Semantic proximity Read ↗

Regulation of imprinted X-chromosome inactivation in mice by <i>Tsix</i>Semantic proximity Read ↗

Tsix-mediated repression of Xist accumulation is not sufficient for normal random X inactivation.Semantic proximity Read ↗

Crucial role of antisense transcription across the Xist promoter in Tsix-mediated Xist chromatin modification.Semantic proximity Read ↗

Xist-dependent imprinted X inactivation and the early developmental consequences of its failure.Semantic proximity Read ↗

De novo DNA methylation is dispensable for the initiation and propagation of X chromosome inactivation.Semantic proximity Read ↗

Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells.Semantic proximity Read ↗

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.Semantic proximity Read ↗

Incomplete X-inactivation initiated by a hypomorphic Xist allele in the mouse.Semantic proximity Read ↗

Tsix transcription across the Xist gene alters chromatin conformation without affecting Xist transcription: implications for X-chromosome inactivation.Semantic proximity Read ↗

Loss of methylation activates Xist in somatic but not in embryonic cells.Semantic proximity Read ↗

A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.Semantic proximity Read ↗

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