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Article

A proximal conserved repeat in the Xist gene is essential as a genomic element for X-inactivation in mouse.

Development (Cambridge, England) - 1 Jan 2009

Hoki Yuko, Kimura Naomi, Kanbayashi Minako, Amakawa Yuko, Ohhata Tatsuya, Sasaki Hiroyuki, Sado Takashi

Abstract excerpt

X-inactivation in female mammals is triggered by the association of non-coding Xist RNA in cis with the X chromosome. Although it has been suggested that the A-repeat located in the proximal part of the Xist RNA is required for chromosomal silencing in ES cells, its role in mouse has not yet been addressed. Here, we deleted the A-repeat in mouse and studied its effects on X-inactivation during embryogenesis. The...

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Identifiers

PMID: 19036803
DOI: 10.1242/dev.026427

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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