Article
9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.
Circulation - 24 Nov 2015
Almontashiri Naif A M, Antoine Darlène, Zhou Xun, Vilmundarson Ragnar O, Zhang Sean X, Hao Kennedy N, Chen Hsiao-Huei, Stewart Alexandre F R
Abstract excerpt
BACKGROUND: The mechanism whereby the 9p21.3 locus confers risk for coronary artery disease remains incompletely understood. Risk alleles are associated with reduced expression of the cell cycle suppressor genes CDKN2A (p16 and p14) and CDKN2B (p15) and increased vascular smooth muscle cell proliferation. We asked whether risk alleles disrupt transcription factor binding to account for this effect. METHODS AND...
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