Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.

Human molecular genetics - 15 Sept 2012

Motterle Anna, Pu Xiangyuan, Wood Harriet, Xiao Qingzhong, Gor Shivani, Ng Fu Liang, Chan Kenneth, Cross Frank, Shohreh Beski, Poston Robin N, Tucker Arthur T, Caulfield Mark J, Ye Shu

Abstract excerpt

Variation on chromosome 9p21 is associated with risk of coronary artery disease (CAD). This genomic region contains the CDKN2A and CDKN2B genes which encode the cell cycle regulators p16(INK4a), p14(ARF) and p15(INK4b) and the ANRIL gene which encodes a non-coding RNA. Vascular smooth muscle cell (VSMC) proliferation plays an important role in the pathogenesis of atherosclerosis which causes CAD. We ascertained...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, Pair 9
Share to Cyclin-Dependent Kinase Inhibitor p15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cyclin-Dependent Kinase Inhibitor p16

Share to Muscle, Smooth, Vascular

Share to Myocytes, Smooth Muscle

Share to Plaque, Atherosclerotic

Share to Primary Cell Culture

Share to RNA, Long Noncoding

Source

Open in PubMed Open full text

Identifiers

PMID: 22706276
DOI: 10.1093/hmg/dds224
PMCID: PMC3428153

Genes

CAD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional analyses of coronary artery disease associated variation on chromosome 9p21 in vascular smooth muscle cells.PMID 22706276Read ↗

Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B.Semantic proximity Read ↗

The 9p21 Locus and its Potential Role in Atherosclerosis Susceptibility; Molecular Mechanisms and Clinical Implications.Semantic proximity Read ↗

Functional genomics of the 9p21.3 locus for atherosclerosis: clarity or confusion?Semantic proximity Read ↗

Expression of Chr9p21 genes CDKN2B (p15(INK4b)), CDKN2A (p16(INK4a), p14(ARF)) and MTAP in human atherosclerotic plaque.Semantic proximity Read ↗

The chromosome 9p21.3 coronary heart disease risk allele is associated with altered gene expression in normal heart and vascular tissues.Semantic proximity Read ↗

9p21.3 Coronary Artery Disease Risk Variants Disrupt TEAD Transcription Factor-Dependent Transforming Growth Factor β Regulation of p16 Expression in Human Aortic Smooth Muscle Cells.Semantic proximity Read ↗

ANRIL expression is associated with atherosclerosis risk at chromosome 9p21.Semantic proximity Read ↗

[Genetic variants, cardiovascular risk and genome-wide association studies].Semantic proximity Read ↗

9p21 and the genetic revolution for coronary artery disease.Semantic proximity Read ↗

Cdkn2a is an atherosclerosis modifier locus that regulates monocyte/macrophage proliferation.Semantic proximity Read ↗

Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.Semantic proximity Read ↗

The CAD risk locus 9p21 increases the risk of vascular calcification in an iPSC-derived VSMC modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.