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Article

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response.

Nature - 10 Feb 2011

Harismendy Olivier, Notani Dimple, Song Xiaoyuan, Rahim Nazli G, Tanasa Bogdan, Heintzman Nathaniel, Ren Bing, Fu Xiang-Dong, Topol Eric J, Rosenfeld Michael G, Frazer Kelly A

Abstract excerpt

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) in the 9p21 gene desert associated with coronary artery disease (CAD) and type 2 diabetes. Despite evidence for a role of the associated interval in neighbouring gene regulation, the biological underpinnings of...

Read the complete abstract on PubMed

Topics

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Share to Chromosomes, Human, Pair 9
Share to Cyclin-Dependent Kinase Inhibitor p15

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endothelial Cells

Share to Enhancer Elements, Genetic

Share to Gene Knockdown Techniques

Share to Interferon-alpha

Share to Purine-Nucleoside Phosphorylase

Share to STAT1 Transcription Factor

Source

Open in PubMed Open full text

Identifiers

PMID: 21307941
DOI: 10.1038/nature09753
PMCID: PMC3079517

Genes

CAD
STAT1
IFNA21
MTAP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21307941-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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