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Article

Functional analysis of the chromosome 9p21.3 coronary artery disease risk locus.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2009

Jarinova Olga, Stewart Alexandre F R, Roberts Robert, Wells George, Lau Paulina, Naing Thet, Buerki Christine, McLean Bradley W, Cook Richard C, Parker Joel S, McPherson Ruth

Abstract excerpt

OBJECTIVE: We have investigated the functional significance of conserved sequences within the 9p21.3 risk locus for coronary artery disease (CAD) and determined the relationship of 9p21.3 to expression of ANRIL and to whole genome gene expression. METHODS AND RESULTS: We demonstrate that a conserved sequence within the 9p21.3 locus has enhancer activity and that the risk variant significantly increases reporter...

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Source

Identifiers

PMID: 19592466
DOI: 10.1161/ATVBAHA.109.189522

Genes

CAD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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