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Article

The E3 ubiquitin ligase activity of RING1B is not essential for early mouse development.

Genes & development - 15 Sept 2015

Illingworth Robert S, Moffat Michael, Mann Abigail R, Read David, Hunter Chris J, Pradeepa Madapura M, Adams Ian R, Bickmore Wendy A

Abstract excerpt

Polycomb-repressive complex 1 (PRC1) and PRC2 maintain repression at many developmental genes in mouse embryonic stem cells and are required for early development. However, it is still unclear how they are targeted and how they function. We show that the ability of RING1B, a core component of PRC1, to ubiquitinate histone H2A is dispensable for early mouse embryonic development and much of the gene repression...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26385961
DOI: 10.1101/gad.268151.115
PMCID: PMC4579347

Genes

PRC1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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