Article
Involvement of the Polycomb-group gene Ring1B in the specification of the anterior-posterior axis in mice.
Development (Cambridge, England) - 1 Sept 2002
Suzuki Maki, Mizutani-Koseki Yoko, Fujimura Yu-Ichi, Miyagishima Hiro, Kaneko Tomomi, Takada Yuki, Akasaka Takeshi, Tanzawa Hideki, Takihara Yoshihiro, Nakano Megumi, Masumoto Hiroshi, Vidal Miguel, Isono Kyo-Ichi, Koseki Haruhiko
Abstract excerpt
The products of the Polycomb group of genes form complexes that maintain the state of transcriptional repression of several genes with relevance to development and in cell proliferation. We have identified Ring1B, the product of the Ring1B gene (Rnf2 - Mouse Genome Informatics), by means of its interaction with the Polycomb group protein Mel18. We describe biochemical and genetic studies directed to understand...
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