Article
Chromatin interaction analyses elucidate the roles of PRC2-bound silencers in mouse development.
Nature genetics - 1 Mar 2020
Ngan Chew Yee, Wong Chee Hong, Tjong Harianto, Wang Wenbo, Goldfeder Rachel L, Choi Cindy, He Hao, Gong Liang, Lin Junyan, Urban Barbara, Chow Julianna, Li Meihong, Lim Joanne, Philip Vivek, Murray Stephen A, Wang Haoyi, Wei Chia-Lin
Abstract excerpt
Lineage-specific gene expression is modulated by a balance between transcriptional activation and repression during animal development. Knowledge about enhancer-centered transcriptional activation has advanced considerably, but silencers and their roles in normal development remain poorly understood. Here, we performed chromatin interaction analyses of Polycomb repressive complex 2 (PRC2), a key inducer of...
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