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Article

Epigenetic regulator function through mouse gastrulation.

Nature - 1 Aug 2020

Grosswendt Stefanie, Kretzmer Helene, Smith Zachary D, Kumar Abhishek Sampath, Hetzel Sara, Wittler Lars, Klages Sven, Timmermann Bernd, Mukherji Shankar, Meissner Alexander

Abstract excerpt

During ontogeny, proliferating cells become restricted in their fate through the combined action of cell-type-specific transcription factors and ubiquitous epigenetic machinery, which recognizes universally available histone residues or nucleotides in a context-dependent manner1,2. The molecular functions of these regulators are generally well understood, but assigning direct developmental roles to them is...

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Identifiers

PMID: 32728215
DOI: 10.1038/s41586-020-2552-x
PMCID: PMC7415732

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