Article
Rnf2 (Ring1b) deficiency causes gastrulation arrest and cell cycle inhibition.
Proceedings of the National Academy of Sciences of the United States of America - 4 Mar 2003
Voncken Jan Willem, Roelen Bernard A J, Roefs Mieke, de Vries Stijn, Verhoeven Els, Marino Silvia, Deschamps Jacqueline, van Lohuizen Maarten
Abstract excerpt
The highly homologous Rnf2 (Ring1b) and Ring1 (Ring1a) proteins were identified as in vivo interactors of the Polycomb Group (PcG) protein Bmi1. Functional ablation of Rnf2 results in gastrulation arrest, in contrast to relatively mild phenotypes in most other PcG gene null mutants belonging to the same functional group, among which is Ring1. Developmental defects occur in both embryonic and extraembryonic...
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