Article

H2AK119ub Safeguards Against Ectopic Transcription Factor Mediated Gene Activation in the Developing Forebrain

2025-07-10

Abstract excerpt

The PRC1 complex regulates developmental gene expression in mammals by ubiquitinating histones (H2AK119ub) and nucleating repressive chromatin interactions. Human genetic data and functional experimentation have demonstrated that H2AK119ub is required for cortical development, however the molecular mechanism for this remains unknown. Here, we show that mouse embryos expressing catalytically deficient RING1B exhibi...

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Literature Corpus work: 462af22e-62bc-59a2-930f-1b80d1828401
DOI: 10.1101/2025.07.07.663591

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