Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

doi:10.1016/j.molcel.2008.11.004

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Article

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

Molecular cell - 21 Nov 2008

Margueron Raphael, Li Guohong, Sarma Kavitha, Blais Alexandre, Zavadil Jiri, Woodcock Christopher L, Dynlacht Brian D, Reinberg Danny

Abstract excerpt

Polycomb group proteins are critical to maintaining gene repression established during Drosophila development. Part of this group forms the PRC2 complex containing Ez that catalyzes di- and trimethylation of histone H3 lysine 27 (H3K37me2/3), marks repressive to transcription. We report that the...

Topics

Animals
Baculoviridae
Cell Line
Cell Line, Tumor
Chromatin
Chromatin Immunoprecipitation
DNA-Binding Proteins
Enhancer of Zeste Homolog 2 Protein
Genes, Reporter
HeLa Cells
Histone-Lysine N-Methyltransferase
Humans
Immunohistochemistry
Jurkat Cells
Kidney

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Identifiers

PMID: 19026781
DOI: 10.1016/j.molcel.2008.11.004
PMCID: PMC3641558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-19026781-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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