Article
Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination.
Molecular cell - 14 May 2010
Eskeland Ragnhild, Leeb Martin, Grimes Graeme R, Kress Clémence, Boyle Shelagh, Sproul Duncan, Gilbert Nick, Fan Yuhong, Skoultchi Arthur I, Wutz Anton, Bickmore Wendy A
Abstract excerpt
How polycomb group proteins repress gene expression in vivo is not known. While histone-modifying activities of the polycomb repressive complexes (PRCs) have been studied extensively, in vitro data have suggested a direct activity of the PRC1 complex in compacting chromatin. Here, we investigate higher-order chromatin compaction of polycomb targets in vivo. We show that PRCs are required to maintain a compact...
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