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Article

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation.

Genes & development - 15 Jul 2015

Pengelly Ana Raquel, Kalb Reinhard, Finkl Katja, Müller Jürg

Abstract excerpt

Histone H2A monoubiquitylation (H2Aub) is considered to be a key effector in transcriptional repression by Polycomb-repressive complex 1 (PRC1). We analyzed Drosophila with a point mutation in the PRC1 subunit Sce that abolishes its H2A ubiquitylase activity or with point mutations in the H2A and H2Av residues ubiquitylated by PRC1. H2Aub is essential for viability and required for efficient histone H3 Lys27...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26178786
DOI: 10.1101/gad.265439.115
PMCID: PMC4526733

Genes

PRC1

Variants

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