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Article

Identification and characterization of a novel CYP2C9 allelic variant in a warfarin-sensitive patient.

Pharmacogenomics - 1 Jan 2015

Dai Da-Peng, Li Chuan-Bao, Wang Shuang-Hu, Cai Jie, Geng Pei-Wu, Zhou Yun-Fang, Hu Guo-Xin, Cai Jian-Ping

Abstract excerpt

AIM: To determine the genetic basis of the low warfarin dose requirement in a Chinese patient. MATERIALS & METHODS: Bi-directional sequencing of CYP2C9, VKORC1 and CYP4F2 genes was performed. CYP2C9 variants were highly expressed in yeast and insect-cell microsomes. Three typical CYP2C9 probe drugs were used to evaluate the catalytic activity. RESULTS: A novel missense mutation (1400 T>C) was identified in CYP2C9...

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Source

Identifiers

PMID: 26255664
DOI: 10.2217/pgs.15.89

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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