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Identification and functional characterization of 11 novel CYP2C19 variants in the Chinese Han population.

Pharmacogenomics - 1 Jan 2025

Lin Qinrong, Xu Wenfeng, Zhang Qiaoling, Lu Zebei, Geng Peiwu, Chen Chunhong, Ma Yuntong, Han Aixia, Liu Rucong, Wu Shangqing, Cai Jianping, Jin Pengfei, Wang Shuanghu, Dai Da-Peng

Abstract excerpt

INTRODUCTION: The cytochrome P450 2C19 (CYP2C19) enzyme plays a critical role in the metabolism of several clinically important drugs, but the genetic polymorphisms of CYP2C19 have been partially characterized in the Chinese population. METHODS: Genomic DNA from 1210 Chinese Han individuals was subjected to next-generation sequencing to screen for CYP2C19 variants, and newly identified mutations were confirmed by...

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Identifiers

PMID: 41640344
DOI: 10.1080/14622416.2026.2624546
PMCID: PMC12915845

Genes

CYP2C19

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