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Article

Four novel defective alleles and comprehensive haplotype analysis of CYP2C9 in Japanese.

Pharmacogenetics and genomics - 1 Jul 2006

Maekawa Keiko, Fukushima-Uesaka Hiromi, Tohkin Masahiro, Hasegawa Ryuichi, Kajio Hiroshi, Kuzuya Nobuaki, Yasuda Kazuki, Kawamoto Manabu, Kamatani Naoyuki, Suzuki Kazuko, Yanagawa Tatsuo, Saito Yoshiro, Sawada Jun-ichi

Abstract excerpt

Genetic variations in cytochrome P450 2C9 (CYP2C9) are known to contribute to interindividual and interethnic variability in response to clinical drugs such as warfarin. In the present study, CYP2C9 from 263 Japanese subjects was resequenced, resulting in the discovery of 62 variations including 32 novel ones. In addition to the two known non-synonymous single nucleotide polymorphisms (SNPs), Ile359Leu (*3;...

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PMID: 16788382
DOI: 10.1097/01.fpc.0000215069.14095.c6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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