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Identification and drug metabolic characterization of four new CYP2C9 variants CYP2C972-75 in the Chinese Han population

13 Dec 2022

Abstract excerpt

Cytochrome 2C9 (CYP2C9), one of the most important drug metabolic enzymes in the human hepatic P450 superfamily, is required for the metabolism of 15% of clinical drugs. Similar to other CYP2C family members, CYP2C9 gene has a high genetic polymorphism which can cause significant racial and inter-individual differences in drug metabolic activity. To better understand the genetic distribution pattern of CYP2C9 in...

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PMID: 36582532
DOI: 10.3389/fphar.2022.1007268

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