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Article

[Identification of a novel CYP2C9 gene mutation (1400T>C) and assessment of its enzymatic activity in vitro].

Zhonghua yi xue za zhi - 26 Nov 2013

Dai Da-peng, Li Chuan-bao, Wang Shuang-hu, Geng Pei-wu, Hu Guo-xin, Cai Jian-ping

Abstract excerpt

OBJECTIVE: To perform a pharmacogenetic study of a patient with warfarin hypersensitivity and determine the biological function of a novel CYP2C9 mutation. METHODS: Genomic DNAs were extracted from the warfarin hypersensitive patient and used for genetic screening of CYP2C9, VKORC1 and CYP4F2 by direct sequencing. Acquired sequences were aligned and blasted with public nucleotide database to clarify whether site...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 24521898

Genes

VKORC1

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