Article
Characterization of a novel CYP2C9 mutation (1009C>A) detected in a warfarin-sensitive patient.
Journal of pharmacological sciences - 1 Jan 2014
Luo Shun-Bin, Li Chuan-Bao, Dai Da-Peng, Wang Shuang-Hu, Wang Zhen-He, Geng Pei-Wu, Cai Jie, Jiang Zhe-Li, Pu Cheng-Wei, Shang Ke, Yuan Xin-Min, Cao Ya-Po, Hu Guo-Xin, Cai Jian-Ping
Abstract excerpt
Warfarin is the most frequently prescribed anticoagulant for the long-term treatment in the clinic. Recent studies have shown that polymorphic alleles within the CYP2C9, VKORC1, and CYP4F2 genes are related to the warfarin dosage requirement. In this study, a novel non-synonymous mutation (1009C>A) in CYP2C9 was detected in a warfarin-hypersensitive patient, while the other two candidate genes were both found to...
Topics
- Aged
- Alleles
- Amino Acid Substitution
- Anticoagulants
- Cytochrome P-450 CYP2C9
- Drug Resistance
- Female
- Genetic Association Studies
- Genetic Variation
- Humans
- Metabolism, Inborn Errors
- Microsomes
- Point Mutation