Article
Identification and Functional Assessment of a New CYP2C9 Allelic Variant CYP2C9*59.
Drug metabolism and disposition: the biological fate of chemicals - 1 Aug 2015
Dai Da-Peng, Wang Shuang-Hu, Li Chuan-Bao, Geng Pei-Wu, Cai Jie, Wang Hao, Hu Guo-Xin, Cai Jian-Ping
Abstract excerpt
CYP2C9, one of the most important drug-metabolizing enzymes, is responsible for metabolizing approximately 15% of clinically important drugs, including warfarin, diclofenac, and losartan. Similar to other CYP members, human CYP2C9 exhibits marked genetic polymorphisms among individuals of different ethnicities. In this study, a novel missense mutation (1300A>T) was identified in a warfarin-sensitive patient after...
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