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Pharmacogenomics of CYP2C9: Functional and Clinical Considerations

28 Dec 2017

Abstract excerpt

CYP2C9 is the most abundant CYP2C subfamily enzyme in human liver and the most important contributor from this subfamily to drug metabolism. Polymorphisms resulting in decreased enzyme activity are common in the CYP2C9 gene and this, combined with narrow therapeutic indices for several key drug substrates, results in some important issues relating to drug safety and efficacy. CYP2C9 substrate selectivity is...

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PMID: 29283396
DOI: 10.3390/jpm8010001

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