Article
CYP2C9 polymorphism analysis in Han Chinese populations: building the largest allele frequency database.
The pharmacogenomics journal - 1 Feb 2014
Dai D-P, Xu R-A, Hu L-M, Wang S-H, Geng P-W, Yang J-F, Yang L-P, Qian J-C, Wang Z-S, Zhu G-H, Zhang X-H, Ge R-S, Hu G-X, Cai J-P
Abstract excerpt
Genetic polymorphisms of CYP2C9 significantly influence the pharmacokinetics and pharmacodynamics of some drugs, which might result in adverse drug effects and therapeutic failure. Several studies have been performed on CYP2C9 genetic polymorphisms in Han Chinese populations. However, these studies only focused on two commonly investigated alleles, *2 and *3, in relatively small sample sizes. To scale up the...
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