Article
Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.
Molecular psychiatry - 1 May 2016
Olfson E, Saccone N L, Johnson E O, Chen L-S, Culverhouse R, Doheny K, Foltz S M, Fox L, Gogarten S M, Hartz S, Hetrick K, Laurie C C, Marosy B, Amin N, Arnett D, Barr R G, Bartz T M, Bertelsen S, Borecki I B, Brown M R, Chasman D I, van Duijn C M, Feitosa M F, Fox E R, Franceschini N, Franco O H, Grove M L, Guo X, Hofman A, Kardia S L R, Morrison A C, Musani S K, Psaty B M, Rao D C, Reiner A P, Rice K, Ridker P M, Rose L M, Schick U M, Schwander K, Uitterlinden A G, Vojinovic D, Wang J-C, Ware E B, Wilson G, Yao J, Zhao W, Breslau N, Hatsukami D, Stitzel J A, Rice J, Goate A, Bierut L J
Abstract excerpt
The common nonsynonymous variant rs16969968 in the α5 nicotinic receptor subunit gene (CHRNA5) is the strongest genetic risk factor for nicotine dependence in European Americans and contributes to risk in African Americans. To comprehensively examine whether other CHRNA5 coding variation influences nicotine dependence risk, we performed targeted sequencing on 1582 nicotine-dependent cases (Fagerström Test for...
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