Article

Rare coding variants in<i>CHRNB2</i>reduce the likelihood of smoking

2022-10-31

Abstract excerpt

Human genetic studies of smoking behavior have been so far largely limited to common variations. Studying rare coding variants has potential to identify new drug targets and refine our understanding of the mechanisms of known targets. We performed an exome-wide association study (ExWAS) of smoking phenotypes in up to 749,459 individuals across multiple ancestries and discovered a protective association signal in C...

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Literature Corpus work: cd1f4a92-f1d4-520e-9c8d-3d006031643f
DOI: 10.1101/2022.10.27.22281470

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