Variants in nicotinic receptors and risk for nicotine dependence.

doi:10.1176/appi.ajp.2008.07111711

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Article

Variants in nicotinic receptors and risk for nicotine dependence.

The American journal of psychiatry - 1 Sept 2008

Bierut Laura Jean, Stitzel Jerry A, Wang Jen C, Hinrichs Anthony L, Grucza Richard A, Xuei Xiaoling, Saccone Nancy L, Saccone Scott F, Bertelsen Sarah, Fox Louis, Horton William J, Breslau Naomi, Budde John, Cloninger C Robert, Dick Danielle M, Foroud Tatiana, Hatsukami Dorothy, Hesselbrock Victor, Johnson Eric O, Kramer John, Kuperman Samuel, Madden Pamela A F, Mayo Kevin, Nurnberger John, Pomerleau Ovide, Porjesz Bernice, Reyes Oliver, Schuckit Marc, Swan Gary, Tischfield Jay A, Edenberg Howard J, Rice John P, Goate Alison M

Abstract excerpt

OBJECTIVE: A recent study provisionally identified numerous genetic variants as risk factors for the transition from smoking to the development of nicotine dependence, including an amino acid change in the alpha5 nicotinic cholinergic receptor (CHRNA5). The purpose of this study was to replicate these findings in an independent data set and more thoroughly investigate the role of genetic variation in the cluster...

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Identifiers

PMID: 18519524
DOI: 10.1176/appi.ajp.2008.07111711
PMCID: PMC2574742

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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