Article
A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence.
Human molecular genetics - 15 Oct 2015
Hancock Dana B, Wang Jen-Chyong, Gaddis Nathan C, Levy Joshua L, Saccone Nancy L, Stitzel Jerry A, Goate Alison, Bierut Laura J, Johnson Eric O
Abstract excerpt
Nicotine dependence is influenced by chromosome 15q25.1 single nucleotide polymorphisms (SNPs), including the missense SNP rs16969968 that alters function of the α5 nicotinic acetylcholine receptor (CHRNA5) and noncoding SNPs that regulate CHRNA5 mRNA expression. We tested for cis-methylation quantitative trait loci (cis-meQTLs) using SNP genotypes and DNA methylation levels measured across the...
Topics
- Adolescent
- Adult
- Black or African American
- Aged
- Aged, 80 and over
- Brain
- Child
- Child, Preschool
- Chromosomes, Human, Pair 15
- DNA Methylation
- Down-Regulation