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Article

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.

Cancer research - 1 Sept 2009

Saccone Nancy L, Wang Jen C, Breslau Naomi, Johnson Eric O, Hatsukami Dorothy, Saccone Scott F, Grucza Richard A, Sun Lingwei, Duan Weimin, Budde John, Culverhouse Robert C, Fox Louis, Hinrichs Anthony L, Steinbach Joseph Henry, Wu Meng, Rice John P, Goate Alison M, Bierut Laura J

Abstract excerpt

Genetic association studies have shown the importance of variants in the CHRNA5-CHRNA3-CHRNB4 cholinergic nicotinic receptor subunit gene cluster on chromosome 15q24-25.1 for the risk of nicotine dependence, smoking, and lung cancer in populations of European descent. We have carried out a detailed study of this region using dense genotyping in both European-Americans and African-Americans. We genotyped 75 known...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19706762
DOI: 10.1158/0008-5472.CAN-09-0786
PMCID: PMC2874321

Genes

CHRNA5
CHRNA3
CHRNB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.PMID 19706762Read ↗

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.Semantic proximity Read ↗

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.Semantic proximity Read ↗

Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.Semantic proximity Read ↗

A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence.Semantic proximity Read ↗

Association and interaction analysis of variants in CHRNA5/CHRNA3/CHRNB4 gene cluster with nicotine dependence in African and European Americans.Semantic proximity Read ↗

Variants in nicotinic receptors and risk for nicotine dependence.Semantic proximity Read ↗

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.Semantic proximity Read ↗

Analysis of detailed phenotype profiles reveals CHRNA5-CHRNA3-CHRNB4 gene cluster association with several nicotine dependence traits.Semantic proximity Read ↗

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution.Semantic proximity Read ↗

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.Semantic proximity Read ↗

Association Between CHRNA3 and CHRNA5 Nicotine Receptor Subunit Gene Variants and Nicotine Dependence in an Isolated Populationof Kashubians in Poland.Semantic proximity Read ↗

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