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Article

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.

PloS one - 1 Jan 2014

Haller Gabe, Li Ping, Esch Caroline, Hsu Simon, Goate Alison M, Steinbach Joe Henry

Abstract excerpt

Smoking is the leading cause of preventable death worldwide. Accordingly, effort has been devoted to determining the genetic variants that contribute to smoking risk. Genome-wide association studies have identified several variants in nicotinic acetylcholine receptor genes that contribute to nicotine dependence risk. We previously undertook pooled sequencing of the coding regions and flanking sequence of the...

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Share to Acetylcholine
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 24804708
DOI: 10.1371/journal.pone.0096753
PMCID: PMC4013067

Genes

CHRNB4
CHRNA3
CHRNA5
CHRNA6
CHRNB3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.PMID 24804708Read ↗

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