Article
Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5.
Human molecular genetics - 15 Aug 2009
Wang Jen C, Cruchaga Carlos, Saccone Nancy L, Bertelsen Sarah, Liu Pengyuan, Budde John P, Duan Weimin, Fox Louis, Grucza Richard A, Kern Jason, Mayo Kevin, Reyes Oliver, Rice John, Saccone Scott F, Spiegel Noah, Steinbach Joseph H, Stitzel Jerry A, Anderson Marshall W, You Ming, Stevens Victoria L, Bierut Laura J, Goate Alison M
Abstract excerpt
Nicotine dependence risk and lung cancer risk are associated with variants in a region of chromosome 15 encompassing genes encoding the nicotinic receptor subunits CHRNA5, CHRNA3 and CHRNB4. To identify potential biological mechanisms that underlie this risk, we tested for cis-acting eQTLs for CHRNA5, CHRNA3 and CHRNB4 in human brain. Using gene expression and disease association studies, we provide evidence that...
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