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Article

Resequencing of nicotinic acetylcholine receptor genes and association of common and rare variants with the Fagerström test for nicotine dependence.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2010

Wessel Jennifer, McDonald Sarah M, Hinds David A, Stokowski Renee P, Javitz Harold S, Kennemer Michael, Krasnow Ruth, Dirks William, Hardin Jill, Pitts Steven J, Michel Martha, Jack Lisa, Ballinger Dennis G, McClure Jennifer B, Swan Gary E, Bergen Andrew W

Abstract excerpt

Common single-nucleotide polymorphisms (SNPs) at nicotinic acetylcholine receptor (nAChR) subunit genes have previously been associated with measures of nicotine dependence. We investigated the contribution of common SNPs and rare single-nucleotide variants (SNVs) in nAChR genes to Fagerström test for nicotine dependence (FTND) scores in treatment-seeking smokers. Exons of 10 genes were resequenced with...

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Identifiers

PMID: 20736995
DOI: 10.1038/npp.2010.120
PMCID: PMC3055324

Genes

CHRNB2
CHRNA4
CHRNA5

Provenance

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