Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

doi:10.1038/tp.2015.149

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Article

Genome-wide meta-analysis reveals common splice site acceptor variant in CHRNA4 associated with nicotine dependence.

Translational psychiatry - 6 Oct 2015

Hancock D B, Reginsson G W, Gaddis N C, Chen X, Saccone N L, Lutz S M, Qaiser B, Sherva R, Steinberg S, Zink F, Stacey S N, Glasheen C, Chen J, Gu F, Frederiksen B N, Loukola A, Gudbjartsson D F, Brüske I, Landi M T, Bickeböller H, Madden P, Farrer L, Kaprio J, Kranzler H R, Gelernter J, Baker T B, Kraft P, Amos C I, Caporaso N E, Hokanson J E, Bierut L J, Thorgeirsson T E, Johnson E O, Stefansson K

Abstract excerpt

We conducted a 1000 Genomes-imputed genome-wide association study (GWAS) meta-analysis for nicotine dependence, defined by the Fagerström Test for Nicotine Dependence in 17 074 ever smokers from five European-ancestry samples. We followed up novel variants in 7469 ever smokers from five independent European-ancestry samples. We identified genome-wide significant association in the alpha-4 nicotinic receptor...

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Identifiers

PMID: 26440539
DOI: 10.1038/tp.2015.149
PMCID: PMC4930126

Genes

CHRNA4

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