Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

doi:10.1002/ajmg.b.30828

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Article

Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2009

Saccone Nancy L, Saccone Scott F, Hinrichs Anthony L, Stitzel Jerry A, Duan Weimin, Pergadia Michele L, Agrawal Arpana, Breslau Naomi, Grucza Richard A, Hatsukami Dorothy, Johnson Eric O, Madden Pamela A F, Swan Gary E, Wang Jen C, Goate Alison M, Rice John P, Bierut Laura J

Abstract excerpt

Tobacco smoking continues to be a leading cause of preventable death. Recent research has underscored the important role of specific cholinergic nicotinic receptor subunit (CHRN) genes in risk for nicotine dependence and smoking. To detect and characterize the influence of genetic variation on vulnerability to nicotine dependence, we analyzed 226 SNPs covering the complete family of 16 CHRN genes, which encode...

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Identifiers

PMID: 19259974
DOI: 10.1002/ajmg.b.30828
PMCID: PMC2693307

Genes

CHRNA3
CHRNA5
CHRNB4
CHRNA4
CHRNA6
CHRNB1
CHRNB3
CHRND
CHRNG

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