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Article

Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.

Human molecular genetics - 1 Feb 2012

Haller Gabe, Druley Todd, Vallania Francesco L, Mitra Robi D, Li Ping, Akk Gustav, Steinbach Joe Henry, Breslau Naomi, Johnson Eric, Hatsukami Dorothy, Stitzel Jerry, Bierut Laura J, Goate Alison M

Abstract excerpt

Genome-wide association studies have identified common variation in the CHRNA5-CHRNA3-CHRNB4 and CHRNA6-CHRNB3 gene clusters that contribute to nicotine dependence. However, the role of rare variation in risk for nicotine dependence in these nicotinic receptor genes has not been studied. We undertook pooled sequencing of the coding regions and flanking sequence of the CHRNA5, CHRNA3, CHRNB4, CHRNA6 and CHRNB3...

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Source

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Identifiers

PMID: 22042774
DOI: 10.1093/hmg/ddr498
PMCID: PMC3259016

Genes

CHRNB4
CHRNA3
CHRNA5
CHRNA6
CHRNB3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence.PMID 22042774Read ↗

Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior.Semantic proximity Read ↗

The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans.Semantic proximity Read ↗

Variants in nicotinic receptors and risk for nicotine dependence.Semantic proximity Read ↗

Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans.Semantic proximity Read ↗

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Rare missense variants in CHRNB3 and CHRNA3 are associated with risk of alcohol and cocaine dependence.Semantic proximity Read ↗

Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.Semantic proximity Read ↗

Rare coding variants in<i>CHRNB2</i>reduce the likelihood of smokingSemantic proximity Read ↗

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