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Article

Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.

Biological psychiatry - 15 Sept 2011

Xie Pingxing, Kranzler Henry R, Krauthammer Michael, Cosgrove Kelly P, Oslin David, Anton Raymond F, Farrer Lindsay A, Picciotto Marina R, Krystal John H, Zhao Hongyu, Gelernter Joel

Abstract excerpt

BACKGROUND: Several studies report association of alpha-4 nicotinic acetylcholine receptors (encoded by CHRNA4) with nicotine dependence (ND). A meta-analysis of genomewide linkage studies for ND implicated a single chromosomal region, which includes CHRNA4, as genome-wide significant. METHODS: After establishing that common variants are unlikely to completely account for this linkage, we investigated the...

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Identifiers

PMID: 21683344
DOI: 10.1016/j.biopsych.2011.04.017
PMCID: PMC3199609

Genes

CHRNA4

Provenance

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