Article
Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans.
Genes, brain, and behavior - 1 Oct 2010
Saccone N L, Schwantes-An T-H, Wang J C, Grucza R A, Breslau N, Hatsukami D, Johnson E O, Rice J P, Goate A M, Bierut L J
Abstract excerpt
Several independent studies show that the chromosome 15q25.1 region, which contains the CHRNA5-CHRNA3-CHRNB4 gene cluster, harbors variants strongly associated with nicotine dependence, other smoking behaviors, lung cancer and chronic obstructive pulmonary disease. We investigated whether variants in other cholinergic nicotinic receptor subunit (CHRN) genes affect the risk of nicotine dependence in a new sample...
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