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Article

The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an AT Motif-Driven Axis.

Cell - 30 Jul 2015

Parsons Michael J, Brancaccio Marco, Sethi Siddharth, Maywood Elizabeth S, Satija Rahul, Edwards Jessica K, Jagannath Aarti, Couch Yvonne, Finelli Mattéa J, Smyllie Nicola J, Esapa Christopher, Butler Rachel, Barnard Alun R, Chesham Johanna E, Saito Shoko, Joynson Greg, Wells Sara, Foster Russell G, Oliver Peter L, Simon Michelle M, Mallon Ann-Marie, Hastings Michael H, Nolan Patrick M

Abstract excerpt

We identified a dominant missense mutation in the SCN transcription factor Zfhx3, termed short circuit (Zfhx3(Sci)), which accelerates circadian locomotor rhythms in mice. ZFHX3 regulates transcription via direct interaction with predicted AT motifs in target genes. The mutant protein has a decreased ability to activate consensus AT motifs in vitro. Using RNA sequencing, we found minimal effects on core clock...

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Identifiers

PMID: 26232227
DOI: 10.1016/j.cell.2015.06.060
PMCID: PMC4537516

Genes

ZFHX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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