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Article

Delayed Cryptochrome Degradation Asymmetrically Alters the Daily Rhythm in Suprachiasmatic Clock Neuron Excitability.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 16 Aug 2017

Wegner Sven, Belle Mino D C, Hughes Alun T L, Diekman Casey O, Piggins Hugh D

Abstract excerpt

Suprachiasmatic nuclei (SCN) neurons contain an intracellular molecular circadian clock and the Cryptochromes (CRY1/2), key transcriptional repressors of this molecular apparatus, are subject to post-translational modification through ubiquitination and targeting for proteosomal degradation by the ubiquitin E3 ligase complex. Loss-of-function point mutations in a component of this ligase complex, Fbxl3, delay...

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Identifiers

PMID: 28698388
DOI: 10.1523/JNEUROSCI.0691-17.2017
PMCID: PMC5559760

Genes

CRY1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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